Core Principle
We do not examine randomly.
We examine to test a hypothesis.
History first
History does not just collect information — it generates a ranked
set of hypotheses. The examination exists to test them.
CTAC still leads
The organ system of primary interest follows from your most likely
diagnosis. Common things are common — start there.
The standard
A clinician who cannot explain why they examined what they examined
has not examined — they have performed a ritual.
What the Examination Is For
"The physical examination is not a search party — it is a
verification exercise."
Purpose 1
Support the most likely diagnosis — find the
expected signs.
Purpose 2
Exclude serious alternatives — look for signs
that would change management urgently.
Purpose 3
Assess severity and complications — findings
that determine how sick this patient is right now.
Note on language: History rarely establishes a
"provisional diagnosis" with certainty — it generates a ranked list of
hypotheses. The examination is how you begin to confirm or discard
them.
The Method
What history generates — and what examination does with it
01
History generates
Hypotheses & priorities
The history gives you a working differential — ranked by
probability. The leading hypothesis determines where you begin.
Ranked differential diagnoses
Organ system of primary interest
Dangerous diagnoses to actively exclude
→
02
Examination is
Targeted verification
You examine the system the history points to — thoroughly and
systematically. Other systems only if the differential demands it.
Primary system — examined in full
Other systems — only if justified
Look for: signs, severity, complications
→
03
Findings either
Confirm or redirect
Examination findings will either reinforce your working hypothesis —
or open a new diagnostic branch you did not anticipate.
Expected signs present → proceed
Expected signs absent → reconsider
Unexpected signs → new hypothesis
Organ System
Finding the system of primary interest — CTAC still applies
CTAC-guided — most common system first
Presenting complaint → Primary system → Targeted examination
| Presenting Complaint |
Primary System |
Key Signs to Seek |
Cross-system Alert |
| Chest pain on exertion |
Cardiovascular |
Pulse character, BP, JVP, heart sounds, signs of heart failure
|
Respiratory (exercise-induced bronchoconstriction)
CVS is the horse — but exertional dyspnoea may point to
both
|
| Chronic cough with purulent sputum |
Respiratory |
Respiratory rate, trachea, percussion, breath sounds, added
sounds
|
Cardiovascular (cardiac cough — nocturnal, non-productive)
If cough is nocturnal and non-productive, consider heart
failure
|
| Epigastric burning pain |
Gastrointestinal |
Epigastric tenderness, succussion splash, hepatomegaly, Murphy's
sign
|
Cardiovascular (inferior MI can present as epigastric pain)
A classic trap — the symptom does not always match the
system
|
| Polyuria and polydipsia |
Endocrine |
Hydration status, BMI, blood pressure, fundoscopy, peripheral
neuropathy
|
Renal (diabetes insipidus — central or nephrogenic)
Type 1 and 2 DM remain the horse — but DI must not be
missed
|
| Acute unilateral limb weakness |
Nervous system |
Power, tone, reflexes, plantar response, cranial nerves, speech
|
Cardiovascular (source of embolism — AF, valvular disease)
Examination of the heart is relevant to prognosis and
recurrence risk
|
What to Look For
Positively and negatively relevant findings
— both matter equally
+
Positively Relevant Findings
Also called: positive findings
Signs that, when present, increase the probability of a diagnosis.
You examine specifically to find — or not find — these.
- Signs characteristic of the leading diagnosis
- Severity markers — how unwell is this patient?
- Complications of the suspected condition
- Signs confirming the organ system is involved
−
Negatively Relevant Findings
Also called: pertinent negatives
Findings whose absence lowers the probability of a
diagnosis. Equally important — and equally deliberate. You look
for them specifically so you can say they are not there.
- Absent oedema in suspected heart failure
- No raised JVP despite clinical HF picture
- No organomegaly in suspected haematological malignancy
- No lymphadenopathy in suspected lymphoma
Key Insight
The absence of an expected finding is not the same as finding
nothing.
A pertinent negative is a deliberate, documented
observation
— not an omission. Saying "no peripheral oedema" tells a different
clinical story from simply not examining the legs.
Examples
History directing examination — in practice
Example 01
Paediatrics · Cardiology
Infant with Respiratory Distress and Poor Feeding
History: An 8-month-old infant with known ventricular
septal defect presents with 2 weeks of poor feeding, sweating during
feeds, and increasing breathlessness. The mother reports reduced
weight gain and longer feeding times.
History points to →
Congestive heart failure
Primary system: Cardiovascular
Exclude: Lower respiratory tract infection
Targeted examination plan — derived directly from history
Examine — with justification
Respiratory rate and work of breathing
Tachypnoea and recessions indicate severity
Heart rate and peripheral perfusion
Tachycardia and prolonged capillary refill suggest
decompensation
Hepatomegaly
Early and sensitive sign of heart failure in infants
Basal crepitations
Suggest pulmonary congestion
Weight and growth centiles
Growth faltering indicates chronic cardiac burden
Do not prioritise — unless indicated
Full neurological examination
No neurological concerns in the history
Detailed musculoskeletal examination
Not relevant to presenting complaint
ENT examination
Only if infection suspected
Clinical reasoning
The history strongly suggests cardiac failure secondary to a
significant left-to-right shunt. Examination is designed to confirm
congestion, assess severity, and exclude infection. If hepatomegaly
and tachycardia are absent, the hypothesis must be reconsidered —
bronchiolitis or pneumonia may be responsible.
In infants, hepatomegaly is often a more reliable sign of heart
failure than peripheral oedema.
Example 02
Paediatrics · Gastroenterology
Chronic Diarrhoea with Growth Faltering
History: A 9-year-old child presents with 5 months of
loose stools, abdominal pain, fatigue, and weight loss. The parent
reports recurrent mouth ulcers and intermittent knee pain.
History points to →
Inflammatory bowel disease
Primary system: Gastrointestinal
Relevant others: Skin, joints, growth
Targeted examination plan — extraintestinal features matter
Examine — with justification
Height, weight, and growth chart review
Growth faltering is a key paediatric severity marker
Pallor
Suggests anaemia from chronic inflammation or blood
loss
Abdominal tenderness or mass
Right iliac fossa mass may suggest Crohn's disease
Perianal inspection
Fissures or skin tags strongly suggest Crohn's
disease
Joint examination
Peripheral arthropathy may accompany active disease
Skin examination
Erythema nodosum or other extraintestinal signs
Do not prioritise — unless indicated
Detailed respiratory examination
No respiratory symptoms reported
Full cardiovascular examination
Baseline observations only unless indicated
Neurological examination
Not suggested by the history
Clinical reasoning
The history strongly suggests inflammatory bowel disease. In children,
growth assessment is essential and cannot be omitted. Examination
extends deliberately beyond the abdomen because inflammatory bowel
disease has systemic manifestations. Each sign sought either
strengthens the hypothesis or broadens the differential.
In paediatrics, growth is a vital sign. Always review centiles in
any child with chronic symptoms.
The Mismatch
When history and examination do not agree
— a diagnostic red flag
Diagnostic Red Flag
History–Examination Mismatch Is Never Irrelevant
Example: History strongly suggests heart failure. But examination
reveals no raised JVP, no oedema, and clear lung bases. What now?
?
Is the history reliable?
Was the history taken completely? Did the patient minimise
symptoms? Is there a communication barrier? Take a collateral
history.
?
Is the patient already treated?
Diuretics will clear oedema. Beta-blockers lower heart rate. A
patient on optimal heart failure therapy may have a normal
examination.
?
Was the examination adequate?
Was the patient fully exposed? Was JVP assessed at 45°? Were lung
bases examined posteriorly? Technique matters.
?
Is the diagnosis wrong?
A clear examination does not mean the history is false — it means
the initial hypothesis may be incorrect. Revise and retest.
?
Is there more than one diagnosis?
Co-existing pathology is common, particularly in older patients.
Two diseases can produce a picture that fits neither perfectly.
!
The mismatch itself is data.
Do not explain it away. Document it. Investigate it. A clinician
who ignores the mismatch has stopped thinking.
The Checklist
Six questions before you examine — make them a habit
Bedside & Viva Checklist
Before you lay a hand on the patient — ask these
Apply to every patient. Every time. Make it automatic.
01
What is the main complaint?
One sentence. The complaint, not the diagnosis.
"Breathlessness for 4 weeks" — not "I think
it's heart failure."
02
Which organ system is primarily involved?
Based on the history, not assumption.
This determines where you begin. If unclear,
begin with the most dangerous system.
03
What are my top three differential diagnoses?
Ranked by probability — CTAC guides you.
Name them before you examine. This is how you
know what to look for.
04
What findings should I look for to support each?
The positively relevant findings — signs that,
if present, would confirm a diagnosis. List them mentally before
you begin.
05
What findings, if absent, would argue against them?
The pertinent negatives — findings you will
specifically look for and document as absent. Not incidentally
absent — deliberately checked.
06
Am I examining purposefully — or performing a ritual?
If you cannot explain why you are examining a system —
you should not be examining it yet. Or you
should revise your differential first.
One more thing: Always obtain consent before
examining. A brief explanation — "I'd like to examine your chest" — is
not a formality. It is part of clinical practice and reflects respect
for the patient.
Take-Home Message
"Examination is not a ritual.
It is a tool to test your clinical
hypothesis."
Every sign you look for should answer a question generated by the
history.
Every sign you find — present or absent — should update your thinking.
History
Hypothesis
→
Examination
Verification
→
Investigations
Confirmation or Revision